Objective: The aim of our study is to assess the effects of Jianpi Bushen recipe joint metformin in endocrine and biochemical festures of Obese polycysticovariansyndrome(PCOS) patients. Method: Twenty-four obsess PCOS patients were administrated metfomin 500 mg three times daily joint Jianpi Bushen recipe one dose of medicine every day

morning and evening hours service for three months. Twenty obsess PCOS patients were administrated metfomin 500 mg three times for three months only. Baseline characteristics were assessed initially and 3 months after treatment in two groups. Result: Fourteen patients achieved regular menstrual periods in integrative medicine group and eleven patients in Metformin group

a significant reduction occurred in waist-hip ratio(WHR)

luteinizing hormone(LH)

androgen(T)

FINS

IAUC

triglyceride(TG)

low density lipoprotein(LDL-c)

ApoB (P<0.05-P<0.01) and a significant increasing occurred in ISI (P<0.01) in integrative medicine group. In metformin group

a significant reduction occurred in WHR

LH

T

FINS

IAUC

ApoB (P≤0.05-<0.01) and ISI increased significantly(P<0.05). Conclusion: Three months of Jianpi Bushen recipe joint metformin can reduce LH and T levels

increase insulin sensitivity and reduce the side effects of metformin

espdcially It was superior in improving lipid metabolism than Metformin therapy in obsess PCOS patients.