Objective: To probe into the pharmacodynamic mechanism of Qilian Shupi(QLSP) recipe by way of researching on its treatment on precancerous lesion of Chronic atrophic gastritis(CAG). Method: Seventy-two patients with precancerous lesions of CAG were divided randomly into two groups

36 of them were treated with QLSP and the other with Wei Fuchun tablet. After three months

the total effective rate

Hp-eradicating rates

gastroscopic images and pathological changes of gastric mucous membranes were observed. Result: The clinical research showed that the total effective rate of QLSP group was 88.9%

while it was 63.9% in Wei Fuchun group; the Hp-eradicating rate of QLSP group was 72%

while it was 43.5% in Wei Fuchun group; QLSP could improve gastroscopic images and pathological results of gastric mucous membrane. Conclusion: Invigorating spleen and tonifying kidney

regulating qi to disperse stagnation

and dispersing accumulation of pathogenic factors to resolve masses are the principles in the management of the precancerous lesion of CAG.