芪仙汤对溃疡性结肠炎患者血清TNF-α,IL-8的影响及疗效观察

陈爱民; 刘永芬; 熊雯雯; 江一平; 洪滔

您当前的位置：

首页 >

文章列表页 >

芪仙汤对溃疡性结肠炎患者血清TNF-α,IL-8的影响及疗效观察

更新时间：2024-01-04

- 芪仙汤对溃疡性结肠炎患者血清TNF-α,IL-8的影响及疗效观察
- Influence and Therapeutic Effect of Qixian Tang on TNF-α and IL-8 in Patients with Ulcerative Colitis
- 中国实验方剂学杂志 2011年17卷第8期页码：255-257
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
移动端阅览
陈爱民, 刘永芬, 熊雯雯, 等. 芪仙汤对溃疡性结肠炎患者血清TNF-α,IL-8的影响及疗效观察[J]. 中国实验方剂学杂志, 2011,17(8):255-257.

CHEN Ai-min, LIU Yong-fen, XONG Wen-wen, et al. Influence and Therapeutic Effect of Qixian Tang on TNF-α and IL-8 in Patients with Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 255-257.
陈爱民, 刘永芬, 熊雯雯, 等. 芪仙汤对溃疡性结肠炎患者血清TNF-α,IL-8的影响及疗效观察[J]. 中国实验方剂学杂志, 2011,17(8):255-257. DOI：

CHEN Ai-min, LIU Yong-fen, XONG Wen-wen, et al. Influence and Therapeutic Effect of Qixian Tang on TNF-α and IL-8 in Patients with Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 255-257. DOI：

摘要

目的: 观察芪仙汤治疗溃疡性结肠炎的效果及探讨芪仙汤对溃疡性结肠炎患者的细胞因子的影响。方法: 将50例溃疡性结肠炎患者随机分成治疗组、对照组。分别予芪仙汤煎剂口服灌肠、柳氮磺胺吡啶片口服

结合地塞米松灌肠治疗。观察临床疗效

并检测治疗前后及25例健康志愿者的血清肿瘤坏死因子(TNF-α)

白细胞介素-8(IL-8)的含量。结果: 治疗组疗效明显优于西药对照组(P<0.05)

治疗组更能显著降低溃疡性结肠炎患者血清TNF-α

IL-8水平。结论: 芪仙汤治疗溃疡性结肠炎疗效显著

可能通过调节溃疡性结肠炎患者细胞因子而达到治疗作用。

Abstract

Objective: To investigate the effects of Qixiantang on TNF-α and IL-8 in patients with ulcerative colitis (UC). Method: Fifty patients with UC were divided into therapy group (25 patients treated with Qixiantang) and control group (25 patients treated with sulfasalazine and dexamethasone).TNF-α and IL-8 in serum were detected by ELISA for all patients before and after treatment

and compared with 25 healthy volunteers. Result: Creative effects in therapy group was obviously better than that in control group

the difference was significance (P<0.05).After treatment

compared with control group

therapy group had the lower plasma levels of TNF-α and IL-8 (P<0.05). Conclusion: Qixiantang is effective for patients with UC. The down regulation of the expressions of TNF-α and IL-8 in serum may be one of the therapeutic mechanism.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

纳米口服结肠靶向给药系统治疗溃疡性结肠炎的研究进展

大黄炒炭前后游离蒽醌与没食子酸在溃疡性结肠炎小鼠体内药代动力学及组织分布比较

茱萸丸“异病同治”肝内胆汁淤积症和溃疡性结肠炎的机制

芍药汤含药血清介导Fas/FasL信号通路抑制脂多糖诱导的Caco-2细胞炎症及凋亡

芍药汤通过调控糖代谢重编程影响Th17/Treg细胞平衡治疗溃疡性结肠炎