糖肾清对DN模型大鼠肾组织形态学的影响

高双荣; 孙翠英; 郑燕飞; 张润云; 金磊; 刘惠; 张春艳; 孟凤仙

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糖肾清对DN模型大鼠肾组织形态学的影响

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- 糖肾清对DN模型大鼠肾组织形态学的影响
- Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy
- 中国实验方剂学杂志 2011年17卷第14期页码：156-159
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(30772762)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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高双荣, 孙翠英, 郑燕飞, 等. 糖肾清对DN模型大鼠肾组织形态学的影响[J]. 中国实验方剂学杂志, 2011,17(14):156-159.

GAO Shuang-rong, SUN Cui-ying, ZHENG Yan-fei, et al. Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 156-159.
高双荣, 孙翠英, 郑燕飞, 等. 糖肾清对DN模型大鼠肾组织形态学的影响[J]. 中国实验方剂学杂志, 2011,17(14):156-159. DOI：

GAO Shuang-rong, SUN Cui-ying, ZHENG Yan-fei, et al. Morphologic Effect of Tangshenqing on Kidney of Rats with Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(14): 156-159. DOI：

摘要

目的: 探讨糖肾清对糖尿病大鼠肾脏形态学的影响。方法 :将SD大鼠随机分为对照组、模型组、阳性药卡托普利(14 mg ·kg-1)组、糖肾清高、中、低剂量(187

93.5

46.75 mg ·kg-1)组

用STZ诱导大鼠糖尿病肾病(DN)模型

连续ig 12周后处死大鼠

取肾脏行HE

PAS染色

光镜下对肾组织病变进行分类评分

PAS染色下测定肾小球系膜基质相对面积。结果 :糖肾清高剂量组的肾脏病变较模型组有所减轻

其肾小球基质相对面积较模型组明显减少(P<0.05)。结论 :糖肾清能减轻DN大鼠肾小球细胞外基质的增生程度

对其肾脏病变具有保护作用。

Abstract

Objective: To investigate morphologic effect of Tangshenqing on kidney of rats with diabetic nephropathy. Method :SD rats were induced diabetic nephropathy by STZ then randomly divided into normal control group

the model group

the positive group

the high dose of Tangshenqing group

the medium dose of Tangshenqing group and the low dose of the group. They were 187

93.5 and 46.75 mg ·kg-1 respectively. After twelve weeks' oral drug administration

the rats were killed and the kidneys were harvested for hematoxylin and eosin and the periodic acid-sliver dyeing. The renal lesions were classified and scored under light microscope. The relative area of mesangium matrix was measured under the periodic acid-sliver dyeing. Result :The renal lesions of the high dose of Tangshenqing group was lightened than the model group. Mesangium matrix relative area of the high dose of Tangshenqing was obviously reduced than the model group (P<0.05). Conclusion :Tangshenqing may relive the extent of mesangium matrix hyperplasia for rats with diabetic nephropathy.

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