Objective: To explore the effect of Wendan Decoction (WDD) on the receptor of glutamic acid (Glu) and N-methyl-D-aspartate (NMDA ) in rats with schizophrenia. Method: Thirty SD rats were divided randomly into 3 groups with 10 in each group: normal group (A)

model group (B) and WDD group (C). WDD group was administered intragatrically with 20 g · kg-1 WDD;the other groups were administered the same volume of normal saline (20 mL ·kg-1). The 3 groups were treated for 21 days. Except the normal group

the other groups were given MK801 with sinistro-intraperitoneal injection to set the schizophrenia model after 1 hour of intragastrical administration in the last 3 days. The dosage was 0.1 mL per 20 g. By the changes in immunohistochemistry and neuropathological morphology

we observed the influence of WDD on expression of receptor Glu in hippocampus

receptor subunit NR1 and NR2B of NMDA and protective effects on pathological injuries in hippocampus of the model rats. Result: The morphological observation showed that there were significant differences in expression of Glu

subunit NR1 and NR2B of NMDA receptor in all groups and there also were significant differences in cell structure and cell denaturalization of CA1 area in hippocampus. Conclusion: WDD can improve disorder of cell rearrangement

relieve the process of nuclei dissolution

postpone the denaturalization of hippocampus cell. It indicates WDD has certain protective effects on pathological injury in hippocampus of the model rats.