Tripterygium wilfordii Hook. f. (TWHF) belongs to Celastraceae. It is a traditional Chinese medicine

with complex chemical constituents and a variety of pharmacological effects. And it is applied for many diseases with significant effects. But the liver toxicity events caused by TWHF were often reported. Liver toxicity caused by TWHF were reviewed in this paper from four aspects including material basis

clinical features

pathological basis and mechanism

in order to provide more reference and methods for clinical safety and scientific research.