Objective: To investigate the effect of the Three-clearing Hypoglycemic Formula(Sanqing Jiangtang Fang) on the blood glucose and blood lipids in type 2 diabetic rats. Method: Ten rats were selected randomly from 82 male Wistar rats to form the normal group(group C). With high fat forage diet of four weeks

the rest 72 rats were injected of small dose of streptozotocin(STZ) intraperitioneally twice to establish rats model with type 2 diabetes. Based on fasting blood sugar levels

the model rats were randomly divided into group treated with high dose of Three-clearing Hypoglycemic Formula(group SG)

group treated with middle dose of Three-clearing Hypoglycemic Formula(group SZ)

group treated with low dose of Three-clearing Hypoglycemic Formula(group SD)

model control group(group M)

group treated with acarbose(group A) and group treated with rosiglitazone(group L). Group SG

group SZ and group SD were administrated with water extracts of Three-clearing Hypoglycemic Formula respectively. Group M was administrated with normal saline. Group A was administrated with acarbose. Compared with group A

group L was administrated with equivalent dosage of rosiglitazone. The sugar tolerances were measured 2 weeks and 4 weeks before and after treatment respectively. Four weeks after treatment

blood was obtained from aorta of rats. blood lipid and hepatic/renal function were tested for further comparisons. Result: ① Four weeks after medicine treatment

there was significant difference between group SD and group M regarding fasting blood glucose levels(P=0.011); ② Four weeks after medicine treatment

there was significant difference in SD group regarding 2 hours-postprandial glucose levels

compared with group SG

group M

group A and group L(P<0.05); ③ Four weeks after medicine treatment

there were no significant difference between each group regarding HDL-c

LDL-c

ALT

AST and crestine levels. Comparing group SZ

group SD

group M and group C

there was significant statistics regarding CHO level(P<0.05). Comparing group SZ

group SD

group A and group C

there was significant difference regarding TG level(P<0.05). Comparing group C with other groups

there was significant difference regarding BUN level(P<0.05). Conclusion: Low dose of Three-clearing Hypoglycemic Formula has better hypoglycemic effect regarding fasting blood glucose and 2 hours-postprandial glucose.