Objective: To investigate the effect of Tongluo Shenggu Capsules on the osteoporosis induced by stress absence. Method: Fourty male SD rats were randomly divided into four groups: normal control

model control

high and low dose drug groups. Besides the normal control group

all animals in other three group were subjected to tail suspension test for 21 days

the animals in drug groups were administered Tongluo Shenggu Capsule. The bone metabolism markers and biomechanical parameters were determined. Reusult: Compared with the nomal control group

the alkaline phosphatase (ALP) and the concentration of calcium in serum of model group was decreased significantly

the area and thickness of bone tranecula

the amount of osteoblast were decreased obviously

compared to the model control

Tongluo Chenggu capsules could increase ALP

the area and thickness of bone tranecula and the osteoblast amount. Conclusion: Tongluo Shenggu Capsules could enhance the growth of bone and could be used to treat osteoporotic induced by stress absence.