Objective: To investigate the pharmacokinetics of phillyrin and phillyrin-baicalin compound after intravenous injection (iv)in rabbits. Method: Ten rabbits were randomly divided into two groups.One group was administered with phillyrin (1 mg ·kg-1)by iv

while the other were treated with phillyrin (1 mg ·kg-1)-baicalin (90 mg ·kg-1)compound by iv.The concentration of CA in plasma was determined by HPLC.The key parameters of pharmacokinetics were calculated and anylyzed by kinetic software.The calibration curve was linear (r=0.997 3)in the range of 1.016-254 mg ·L-1. Result: Concentration-time courses of phillyrin alone and phillyrin-baicalin compound were consistent with non-compartment model after iv.The key pharmacokinetic parameters of phillyrin alone were different with that of phillyrin-baicalin compound (P<0.05). Conclusion: Baicalin can affect the pharmacokinetics of constituent phillyrin in rabbits.