Objective: To study the experimental anti-arrhythmia and anti-hypertensive effects of extract from Menispermum dahuricum (MD). Method: The experimental arrhythmia model in rat was caused by aconitine and BaCl2.The blood pressure was measured.The occurrence of VA

VT

VF caused by aconitine in rats was recorded

and arrhythmias caused by BaCl2 in rats was recorded.Blood pressure was monitored in rats before and after the treatment of extract from MD. Result: MD (40 mg ·kg-1

iv) could significantly increase the amount of aconitine for inducing VP and VT in rats;MD (40

20 mg ·kg-1

iv) could increase amounts of aconitine for inducing VF in rats.MD (40

20 mg ·kg-1

iv) could delay the occurrence of arrhythmia induced by BaCl2 and shorten the duration of arrhythmia in rats.MD (40 mg ·kg-1) showed obvious anti-hypertensive effect

the anti-hypertensive duration was lasted significantly. Conclusion: MD has significant protective effect to the experimental arrhythmia induced by drugs.MD has lasting anti-hypertensive effect.The anti-arrhythmic mechanism is likely related to inhibition of transmembrane movement of Ca2+ and Na+.