Objective: To observe effects of oils in Alpinia officinarum Hance(OAOH) on serum gastrointestinal hormones in gastrelcosis mice model. Method: ICR mice were randomly divided into 7 groups:control group

model group

liangfu pills group (2 g ·kg-1)racanisodimine group(0.005 g ·kg-1)

OAOH low dose group

OAOH middle dose group

OAOH high dose group(2

4

8 mL ·kg-1).The gastrelcosis mice model was induced by reserpine

which was then given drugs for 6 days.The content of motilin(MOT)

somatostatin(SS)

substance P(SP)

vasoactive in testinal peptide(VIP) in serum were determined by ELISA. Result: Compared with the model group:① All the treatment decreased ulcer index and increased ulcer inhibition rate(P<0.01).②OAOH

liangfu pills

group racanisodimine obviously decreased MOT

SP in serum(P<0.01

P<0.05)

significantly increased SS in serum (P<0.01

P<0.05);High dose OAOH increased VIP content in serum(P<0.01). Conclusion: OAOH treats gastrelcosis by reducing the content of MOT and SP

increaseing the content of SS and VIP in serum.