Objective: To observe the effect on the treatment for gastroesophageal reflux disease with reinforcing spleen and stomach. Method: One hundred and six cases are randomly divided to the therapy group (56 cases) and the control group (50 cases). The therapy group was treated by Chinese materia medica decoction. the control group was treated by omeprazole and domperidone. The course of treatment was 30 days. The follow-up was done 30 days after the treatment. Result: After a course of treatment

the effective rate of two groups was 98.2% and 94.0% respectively; the effective rate of the therapy group was higher than that of the control group

the difference between two groups had a distinct significance(P<0.05). The therapy group obviously improved scores of each symptom and reflux diseases questionnaire. Conclusion : The effect of the treatment for gastroesophageal reflux disease with reinforcing spleen and stomach is sure.