Objective: To observe the influence of Jingang wine on the kidney yang and sexual function in rat model and mouse model with deficiency of kidney yang. Method: Rat model and mouse model of deficiency of kidney yang were made by intramuscular injection of hydrocortisone. The animal models were divided into control group

model group

positive group

and Jingang wine group (low doses

middle dose

and high dose

given 10 days). The pharmacological action of the wine was evaluated by body weight

autonomous activities

survival time of animal in hypothermia swimming

prostate weight and seminal vesicle weight

endurance time in hypooxygen

and sex organ accessories in male castrated rats. Result: Compared with the model group

there were obvious difference in the growth rate of weight

prostate weight and seminal vesicle weight

swimming time

and autonomous activities among different dose Jingang wine groups(P<0.05). There was obvious difference in endurance time in hypooxygen condition compared with that of the control group(P<0.05). Compared with the model group

there were obvious differences in erection time and sex organ accessories in the castrated male rats

such as prostate and seminal vesicle and levator ani(P<0.05). Conclusion: Jingang wine would nourish the kidney and support yang

and could improve sexual atrophy and function.