Objective: To investigate the clinical effects of Diane-35 with metformin on treating women with polycystic ovary syndrome(PCOS). Method: Thirty-eight patients took orally Diane-35 and metformin for 3 consecutive courses of treatment.Clinical symptoms

luteinizing hormone(LH)

follicle stimulating hormone(FSH)

T

Leptin

HOMA-IR

SHBG

BMI and the ovarian volume were kept under observation before and after taking Diane-35 and metformin.Reproductive hormones

serum glucose and insulin level were compared to that before therapy. Result: The content of LH/FSH

androgen

HOMA-IR were less than that before the treatmennt.The content of SHBG was more than that before taking medicine

and there were highly significant difference (P<0.01).The content of BMI was less than that before taking medicine

the size of ovaries was reduced and there were significant difference (P<0.05). Conclusion: Diane-35 and metformin are effective to reduce insulin resistance and androgen and to recover ovulation in women with PCOS.And the treatment was shown to be safe and effective.