Objective: To observe the effect of Fructus Bruceae oil emulsion (FBE) combined with chemotherapy on immune function in patients with advanced non-small-cell lung cancer (NSCLC). Method: One hundred and fifty-six patients with advanced NSCLC were randomly assigned to two groups

the 74 patients in the control group were only treated with chemotherapy of GP regimen

84 in the treatment group with the chemotherapy of the same regimen and combined with FBE.The cellular immune(CD3+

CD4+

CD8+

CD16+ CD56+)and humoral immunity(IgG

IgA

IgM

C3

C4)were tested by immunocytochemistry method and biochemistry method respectively.The treatment effects on immune were compared between before and after chemotherapy. Result: The response rates were 40.3% in the treatment group and 36.5% in the control group

there was no statistical difference between them.Compare before chemotherapy

the cellular immune function in the control group was decreased

which was increased in the treatment group.The cellular immune function in the treatment group was better than that in the control group after chemotherapy(P＜0.05 or P＜0.01).No visible change in humoral immune was found in each group. Conclusion: FBE combined with chemotherapy of GP regimen can improve the cellular immune function in patients with advanced NSCLC.