Objective: To study the therapeutic effect of citalopram combined with Shenshuaining pill (SSNP) in the treatment of post-stroke depression. Method: Eighty post-stroke depression patients were randomly assigned into treated (citalopram combined with SSNP) and control (citalopram) groups (each n =40) for 6 weeks.Anti-depression therapeutic effect

neural functional impairment and adverse reactions were assessed with the hamilton depression scale (HAMD)

the modified Edinburgh-Scandinavia stroke scale (MESSS)

and the Treatment Emergent Symptom Scale(TESS)respectively. Result: In the treatment group

the scores of the HAMD and TESS distinguished markedly at the end of the 1st and 2st weeks

and the total scores of the MESSS were 14.22±4.53 in treatment groups at the end of the 6th were

compared with control group(17.38±5.10)

they decreased significantly distinguished( P <0.05). Conclusion: Citalopram combined with SSNP had superior therapeutic effect for neural function recovery

and was a kind of rapid and safe drug in the treatment of post-stroke depression.