Objective: To improve the dosage form of Xinshenger Tuihuang mixture (XTM) and to change the administration route

and to observe its curative effect on neonatal jaundice. Method: Water extraction and alcohol precipitation preparation for improving XTM were used

lotion and enteroclyster were prepared. Patients conforming to inclusion criteria were randomly divided into observation group A

B and control group( n ＝60 each). Control group was given oral dose of phenobarbital sodium 8 mg ·kg-1

tid. for 4 d; observation group A was given oral dose of XTM 10 mL

tid. for 4 d;and observation group B was given Chinese materia medica as enteroclysm combined with medicated bath bid. for 4 d.Then we detected serum bilirubin(SB)level

compared the effects of jaundice-abating between three groups. Result: Compared with control group

Observation group B was statistical significance( P ＜0.01). Compared with observation group A

the total effective rate in observation group B was raised( P ＜0.05). Conclusion: Chinese materia medica as enteroclysm combined with medicated bath is effective in the treatment of neonatal jaundice. Compared with oral administration it is convenient and deserved to spread in clinic.