Objective: To investigate the effects of Qiaojing Bushen capsule(QJBS) on the kidneyharmin rats of diabetes models. Method: Diabetes rats model are established by 30 mg ·kg-1 streptozocin(STZ) and the high fat feed. The SD rats were randomly divided into four groups:model control group

Xiaokewan-treated group

high-doses QJBS group and low-doses group QJBS group. Filling the stomach with the medicine

once a day

continuously 8 weeks

we observed 24 h urinary albumin excretion rate(UAER) excretion rate and the blood and urinates creatinine and the endogenous endogenous percentage clearance in rats of each group. Result: Compared with the model group

medicinal treatment group can reduce 24 hUAER excretion rate obviously and the blood endogenous content

but increases the urine endogenous excretion quantity and the urine endogenous percentage clearance. QJBS and other medicinal groups can improve the kidney pathological change in varying degree. QJBS low dosage group’s function was not remarkable. Conclusion: QJBS could inhibit mice kidney damage induced by STZ of type 2 DM.