枯芩中清热黄酮类药效组分的测定

崔萌萌; 张贵君; 徐蓓蕾; 黄睿

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枯芩中清热黄酮类药效组分的测定

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- 枯芩中清热黄酮类药效组分的测定
- Determination of Active Components Alignments of Flavonoids for Clear Away Heat from Hollow Root of Baikal Skullcap
- 中国实验方剂学杂志 2011年17卷第4期页码：83-86
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- 纸质出版日期：2011
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崔萌萌, 张贵君, 徐蓓蕾, 等. 枯芩中清热黄酮类药效组分的测定[J]. 中国实验方剂学杂志, 2011,17(4):83-86.

CUI Meng-meng, ZHANG Gui-jun, XU Bei-lei, et al. Determination of Active Components Alignments of Flavonoids for Clear Away Heat from Hollow Root of Baikal Skullcap[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 83-86.
崔萌萌, 张贵君, 徐蓓蕾, 等. 枯芩中清热黄酮类药效组分的测定[J]. 中国实验方剂学杂志, 2011,17(4):83-86. DOI：

CUI Meng-meng, ZHANG Gui-jun, XU Bei-lei, et al. Determination of Active Components Alignments of Flavonoids for Clear Away Heat from Hollow Root of Baikal Skullcap[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 83-86. DOI：

摘要

目的 :测定枯芩中4种黄酮类药效组分

为建立黄芩类中药与疗效对应的质量标准提供科学依据。方法 :采用药对配伍组分-液相色谱综合分析法。结果 :药效组分黄芩苷-黄芩素-汉黄芩苷-汉黄芩素含量为(75.83±7.25)

(2.72±0.53)

(18.62±2.89)

(1.44±0.37) mg ·g-1。结论 :枯芩中黄酮类药效组分黄芩苷-黄芩素-汉黄芩苷-汉黄芩素

比例为52.44 ∶1.89 ∶12.88 ∶1

有清热燥湿作用

与子芩比较有极显著性差异(P<0.01)

建议分别建立黄芩类中药药效组分质量评价指标。

Abstract

Objective: To determine the active components alignments (ACA) of four flavonoids in hollow root of Baikal Skullcap (hollow root of Scutellaria baicalensis )

so as to provide scientific basis for the establishment of quality standard in accordance with its therapeutic. Method: The ACA were determined by reversed phase high-performance liquid chromatography (RP-HPLC) & herb-herb compatibility. Result: The content of Baicalin-Baicalein-Wogonoside-Wogonin in four formulas of hollow root of Baikal Skullcap was (75.83±7.25)

(2.72±0.53)

(18.62±2.89)

(1.44±0.37) mg ·g-1. Conclusion: The ACA ratio of flavonoids in hollow root of Baikal Skullcap was 52.44 ∶1.89 ∶12.88 ∶1

with the action of clearing away lung-heat.There were high significant differences between hollow roots and lateral root of Baikal Skullcap (P<0.01).Therefore

the quality evaluation criteria of hollow roots and solid lateral root of Baikal Skullcap should be established separately.

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枯芩中清热黄酮类药效组分的测定