通脉糖眼明胶囊对单纯型糖尿病视网膜病变患者VEGF水平的影响

徐寒松; 孔德明; 向慧

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通脉糖眼明胶囊对单纯型糖尿病视网膜病变患者VEGF水平的影响

更新时间：2024-01-04

- 通脉糖眼明胶囊对单纯型糖尿病视网膜病变患者VEGF水平的影响
- Effect of Tongmai Tangyanming Capsule on Levels of Vascular EndothelialGrowth Factor in Patients with Non-proliferative Diabetic Retinopathy
- 中国实验方剂学杂志 2011年17卷第12期页码：229-231
- 作者机构：
- 作者简介：
- 基金信息：
  
  贵州省卫生厅基金项目(2002149)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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徐寒松, 孔德明, 向慧. 通脉糖眼明胶囊对单纯型糖尿病视网膜病变患者VEGF水平的影响[J]. 中国实验方剂学杂志, 2011,17(12):229-231.

XU Han-song, KONG De-ming, XIANG Hui. Effect of Tongmai Tangyanming Capsule on Levels of Vascular EndothelialGrowth Factor in Patients with Non-proliferative Diabetic Retinopathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 229-231.
徐寒松, 孔德明, 向慧. 通脉糖眼明胶囊对单纯型糖尿病视网膜病变患者VEGF水平的影响[J]. 中国实验方剂学杂志, 2011,17(12):229-231. DOI：

XU Han-song, KONG De-ming, XIANG Hui. Effect of Tongmai Tangyanming Capsule on Levels of Vascular EndothelialGrowth Factor in Patients with Non-proliferative Diabetic Retinopathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 229-231. DOI：

摘要

目的: 观察通脉糖眼明胶囊对单纯型糖尿病视网膜病变(diabetic retinopathy

DR)患者血管内皮生长因子(vascular endothelial growth factor

VEGF)水平的影响

探讨通脉糖眼明胶囊治疗糖尿病视网膜病变的可能机制。方法: DR患者68例随机分为通脉糖眼明胶囊治疗组36例

对照组32例

同时收集同年龄健康者30例为正常组

治疗组予通脉糖眼明胶囊治疗

比较治疗前后3组VEGF水平的变化。结果: DR患者VEGF水平显著升高

与正常组比较

差异有显著性意义(P<0.01);治疗8周后VEGF水平均下降

与治疗前相比差异有显著性意义(P<0.01);通脉糖眼明胶囊治疗组VEGF水平(116.50±22.34)下降尤为显著

与对照组(136.4±24.6)相比

差异有显著性意义(P<0.01)。结论: 通脉糖眼明胶囊能有效降低DR患者VEGF水平

从而缓解DR病变进程。

Abstract

Objective: To observe the effects and possible mechanism of Tongmai Tangyanming capsule on the levels of vascular endothelial growth factor(VEGF) in patients with non-proliferative diabetic retinopathy(DR). Method: Sixty-eight DR patients were randomly divided into 36 of tongmai tangyanming capsule treatment group and 32 of control group.30 of normal subject as normal group.The levels of VEGF were measured in three group pre and post treatment. Result: Serum levels of VEGF in DR group were significantly higher than those of the normal group (P<0.01).after 8 weeks treatment

when comparing with that before treatment

the levels of VEGF were decreased(P<0.01); Compared with control group

the levels of VEGF in the treated group decreased significantly(P<0.01). Conclusion: Tongmai tangyanming capsule can effectively decrease the levels of VEGF in DR patients

so that partly suppresses the development of diabetic retinopathy.

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