Objective: To investigate whether schizonepetin has any influences on the cardiovascular system

the nervous system and the respiratory system of animals. Method: Mice and rats were given oral medicine with different doses of ST in order to evaluate the effects of ST on sleep and the autonomous movement in rats

on the falling number of mice from the rotating stick. Anesthetized dogs were given oral medicine with different doses of ST in order to evaluate the effects of ST on the frequency and depth of respiration

systolic and diastolic blood pressure (SAP

DAP)

heart rate (HR)

PR

QRS

QT and T-wave. Result: With the dosage

ST had no obvious effect on the number of sleep and the autonomous movement in rats

on the falling number of mice from the rotating stick. With the dosage

ST had no obvious effect on the frequency and depth of respiration

systolic and diastolic blood pressure

heart rate

PR

QRS

QT and T-wave. Conclusion: Experimental dosage for mice

20 times of the clinical adult dosage

is the half dose of LD50 for mice. The study indicates that at this level of dosage ST has no obvious effects on respiratory

cardiovascular and nervous systems.