Objective: Screen the extraction process of Tongfengding granules by the mouse model of hyperuricemia. Method: Given by gavage uricase inhibitor potassium oxide hydrochloride manufacture of high uric acid (UA) mouse model of hyperlipidemia

the mice were fed grain with water extraction

water extraction and alcohol precipitation

70% ethanol extracts derived from extracts of Tongfending graules

and then the concentrations of uric acid in the blood of each group (SUA) were determined by UV spectrophotometer. Result: Compared with normal group

the serum uric acid levels in model group mice were significantly higher (P<0.001);compared with model group

the water extract obtained extract could significantly reduce the high uric acid levels in mice serum uric acid (P<0.01); supernatant and precipitation part in water extraction and alcohol precipitation had no significant impact on serum uric acid levels of high serum uric acid mice; 70% ethanol extracts could significantly increase serum uric acid levels in model group mice (P<0.001). Conclusion: Water extraction from the clinical setting for Tongfengding graules is the best particle extraction.