Objective: To study the effect of local application of Qingpeng Paste for treating adjuvant arthritis (AA) in rats. Method: Ten rats was eandomly selected form fifty rats as the normal control

the other rats were used to made the adjuvant arthritis model. The model was induced by injection of Freund’s complete adjuvant. Then

the fourty rats were divided into model group

Qingpeng Paste high dose group (1.6 g ·kg-1) and Qingpeng Paste low dose group (0.4 g ·kg-1). The influence on swelling of the rear leg

the serum nitric oxide (NO) and interleukin-1β(IL-1β) level in the adjuvant arthritis rats were observed. HE staining was used to examine the pathological changes in joint synovium of the rat after using Qingpeng Paste locally. Result: Qingpeng Paste significantly decreased swelling of joints in AA rats compared with the control (P<0.05). the levels of NO of the rats in Qingpeng Paste groups were significantly decreased compared with the control (P<0.05). However

the level of IL-1β did not change. The pathological changes un the synovium tissues were markedly ameliorated in Qingpeng Paste groups. Conclusion: Qingpeng Paste can ameliorate the symptom of adjuvant arthritis in rats.