Objective: To optimize the extract process of total lignans from Schisandra sphenanthera. Method: The best extraction conditions were determined by ultraviolet spectrophotometry method and HPLC method based on the test of total lignans from S.sphenanthera; and the orthogonal experiment design was used with a total lignans

fructus schisandrae chinensis and schizandrol A as evaluation indexes

using reflux extraction method with extraction time

ethanol concentration

solvent dosage

extraction times as factors. Result: The optimal extracting process was as follows: 16 times of 55% ethanol solvent consumption

extracted for 60min with 2 times. Conclusion: The extraction process of Schisandra sphenanthera objectively optimized by multi-index synthetic evaluation method can provide the reference for the purification research of total lignans from S. sphenanthera.