Objective: To evaluate the anti-inflammatory and analgesic effects of ligustilide. Method: The pharmacodynamic effects were observed in 2 analgesic tests and 4 inflammatory models in experimental animals

including:hot plate test in mice

writhing reaction induced by acetic acid in mice

increased permeability of abdominal cavity induced by acetic acid in mice

auricular edema induced by dimethy benzene in mice

paw swelling caused by carrageenan in rats

cotton-pellet granuloma in rats. Result: Ligustilide (100

60

20 mg ·kg-1) could delay the latency of licking of the hind paw in hot plate test.And it could reduce the times of writhe response actions

and the inhibition rates were 61.21%

48.12%

43.61% accordingly.Ligustilide could distinctively inhibit the increase in permeability of abdominal cavity induced by acetic acid in mice

and the inhibition rates were 64.84%

57.85%

49.67% respectively.Ligustilide could significantly inhibit the auricular edema induced by dimethy benzene

and the inhibition rates were 52.06%

41.51%

34.21%.Ligustilide could significantly inhibit the paw swelling caused by carrageenan in rats

and the inhibition rates were more than 42% from 1 to 3 hour.Ligustilide could significantly inhibit the cotton-pellet granuloma in rats

and the inhibition rates were 52.64%

50.32%

45.33%. Conclusion: Ligustilide has an analgestic effect and can significant inhibit acute and chronic inflammation in animals.