Objective: To explore the effect of Guben Yishen Capsule(GB-C)on the hemorheological parameters for acute blood stasis in rats and mice. Method: The model of blood stasis in rats was prepared by injection of 0.1% epinephrine and putting them into ice-water for several minutes. The model of stasis in mice was established in the similar manner. The whole blood viscosities at low

middleand high shear rates

plasma viscosity

serum viscosity

fibrinogen viscosity

whole blood reduction viscosity

hematocrit

platelet aggregation resistance index and the clotting-time of mice were measured. Result: GB-C at 2.25

0.75 g ·kg-1 doses could markedly decrease the whole blood viscosities at low

middle and high shear rates

plasma viscosity

fibrinogen viscosity

and whole blood reduction viscosities at low

high shear rates and hematocrit were decreased

decrease platelet aggregation resistance index

and the clotting-time of mice was extended(P＜0.05

P＜0.01). Conclusion: GB-C can ameliorate the indexes in hemorheology in animals with acute blood stasis.