Objective: To observe the effects of Danqing Soft Capsule (DSC) on rat with non-alcoholic fatty liver (NAFLD). Method: The SD rats were randomly divided into control group

model group

DSC high dose group

medium dose group

low dose group

and polyene phosphatidyl choline (PPC) group.Non-alcoholic fatty liver disease model in SD rats was established with high fat diet.DSC high dose group

medium dose group and low dose group were intervened with different concentrations of DSC

which are respectively equivalent to petroleum ether extract of salvia 0.456

0.228

0.114 g ·kg-1.PPC group was intervened with PPC of 0.159 g ·kg-1ig.Control group and model group were administered the same volume (1.2 mL ·kg-1

ig) of distilled water.After treatment for 4 weeks

rat liver pathological changes

TG

TC level

and blood lipids levels were observed. Result: The levels of TC

TG

LDL-C in serum and the levels of TG and TC in liver of control group

traditional Chinese medicine (TCM) groups and western medicine (WM) group were significantly lower than those of model group (P<0.01

P<0.05).Compared with those in model group

the degrees of fatty degeneration of liver cells in TCM groups and WM group were significantly improved (P<0.01). Conclusion: DSC can reduce the level of TG

TC

LDL in serum as well as the level of TG and TC in liver.It can improve the steatosis of liver in rats with NAFLD.