Objective: This study was designed to screen different combination of astragalus active ingredients for blood sugar regulation in diabetes rats

and to find the influences on blood glucose

serum insulin and adiponectin. Method: Diabetes rats were induced by STZ (52 mg ·kg-1

peritioneal injection )

some of which were administered by different combination of astragalus flavonoids

polysaccharides

and astragalosides for 30 days

the control group was parallelly established. After the treatment

detection of blood glucose and ELISA assay of serum insulin and adiponectin were carried out. Result: Body weight of diabetes rats was dropped

the blood glucose of diabetes was ascended

serum insulin and adiponectin descended(P<0.05).The blood glucose descended in astragalus flavonoid+astragalosides group (body weight gained for the group); astragalus group

astragalus flavonoid+polysaccharides group

astragalus flavonoid+astragalosides group and astragalus flavonoid+polysaccharides+astragalosides group. The best group was astragalus group for ascending serum insulin(P<0.05). The treatment groups showed regulative effect on serum adiponectin

the effect of astragalus group

astragalus flavonoid+astragalosides group and astragalus flavonoid+polysaccharides+astragalosides group were obvious(P<0.05). Conclusion: Astragalus and different combination of its active ingredients could influence the content of blood glucose

serum insulin and adiponectin in diabetes rats

the best result came from astragalus flavonoid+astragalosides group.