Objective: To study the effect of Shengmaiyin and its crude compositions extract on isolated normal and failure heart model. Method : Failure model of isolated heart was made by ligating coronary artery

then the hearts were perfused by Working Heart system. Polygraph was used to determine cardiac function affected by different drugs. Result : Shengmaiyin of different concentrations could cause the left ventricular systolic pressure

the maximum rise or decline rate of left ventricular pressure and coronary blood flow to increase in a concentration-dependent manner. Renshenfang was a little better than Dangshenfang. As compositions of Shengmaiyin

Hongshen and Ophiopogonic Radix had a positive effect on cardiac function

of which two parts of Ophiopogonis Radix crude extracts

Maidong-30 and saponin all had a great effect on left intraventricular pressure maximum alleosis rate. Conclusion : The main materials of Shengmaiyin affected positively for isolated failure heart are two compositions of Ophiopogonic Radix:Ophiopogonic Radix-30 and saponin.