Objective: To investigate the effect of Jingluoshu Capsule for activating blood circulation to remove blood stasis (ABCRBS)

and its analgestic and anti-inflammatory action in diabetic rats. Method: High

medium and low dose groups of Jingluoshu Capsule

1.4

0.7

0.35 g ·kg-1in rats and 2.8

1.4

0.7 g ·kg-1in mice accordingly

were established.

Positive medicine (Tangmaikang Grannules) was ig given once daily at the dose of 2.5 g ·kg-1.The diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) in Wistar rats.The animals were randomly divided into normal control group

model control group

positive medicine control group

positive control group of Chinese medicine

high

medium and low dose groups of.Jingluoshu Capsule.of the efficacy of the drugs was evaluated with hemorrheological parameters

anti-inflammation and analgestic tests. Result: Jingluoshu Capsule could decrease the whole blood viscosity at high shear rate

show inhibitory action on the increase in capillary permeability induced by histamine.The capsule significantly inhibited the formation of granuloma induced with cotton ball.After 30 and 60 minutes of administration

it could prolong the time of first licking feet in the hot-plate test in mice and increase the pain threshold.The capsule could also significantly decrease the number of twisting body induced by acetic acid in mice

showing a significant analgesic effect. Conclusion: Jingluoshu Capsule has significant effect of activating blood circulation to remove blood stasis

and anti-inflammatory

analgestic actions in diabetic rats.