Objective: To optimize the technical conditions of ethanol percolation extraction for Citri Grandis Exocarpium Plaster. Method: The content of naringin extracted from Citri Grandis Exocarpium

which was regarded as the marker of detection

was determined by high performance liquid chromatography and was used to optimize the extraction processing conditions by L9(34) orthogonal test. Result: The optimum extraction condition was that the concentration of ethanol was 80%

the volume of solvent was 15 times of medicinal materials

the soaking time was 24 hours and the percolating speed was 5 mL ·min-1 ·kg-1. The average transferring rate of naringin in 3 batches of samples was 79.0%. Conclusion: The optimum extraction process is reasonable and the transferring rate of naringin is higher.