Objective: By chronic stress and spleen damp-heat to explore the combination of traditional Chinese medicine syndrome with IBS in animal model. Method :Thirty SD rats were randomly divided into 3 groups

namely: the blank group

model groupⅠ(Spleen and Stomach Damp-heat group)

model groupⅡ(composite model group)

each of 10 rats. Except the blank group

the model groupⅠand group Ⅱ were the spleen damp-heat modeling groups. However group Ⅱ was simultaneously with irritable bowel syndrome by chronic stress methods. By the end

the physiological indices of rats and histological changes were investigated. Result: In the model groups

body weight

body temperature

fecal character and behavior were significant different compared with the control group(P<0.05). However in the intestine there was no significant histological difference. Conclusion: Damp-heat diarrhea-type IBS of rat model is to some extent to human diarrhea-predominant IBS(spleen type) with good repeatability.