白芍提取物对嗅球损毁抑郁模型大鼠 行为学及下丘脑-垂体-肾上腺轴的影响

王景霞; 张建军; 苗春平; 刘妍; 林清; 陈振振

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白芍提取物对嗅球损毁抑郁模型大鼠行为学及下丘脑-垂体-肾上腺轴的影响

更新时间：2024-01-04

- 白芍提取物对嗅球损毁抑郁模型大鼠行为学及下丘脑-垂体-肾上腺轴的影响
- Influences of Extract of Peony Radix Alba on Behavior and Hypothalamic-pituitary-adrenocortical Axis in Depressive Rats Model with Damaged Olfactory Bulb
- 中国实验方剂学杂志 2011年17卷第3期页码：155-158
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- 纸质出版日期：2011
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王景霞, 张建军, 苗春平, 等. 白芍提取物对嗅球损毁抑郁模型大鼠行为学及下丘脑-垂体-肾上腺轴的影响[J]. 中国实验方剂学杂志, 2011,17(3):155-158.

WANG Jing-xia, ZHANG Jian-jun, MIAO Chun-ping, et al. Influences of Extract of Peony Radix Alba on Behavior and Hypothalamic-pituitary-adrenocortical Axis in Depressive Rats Model with Damaged Olfactory Bulb[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 155-158.
王景霞, 张建军, 苗春平, 等. 白芍提取物对嗅球损毁抑郁模型大鼠行为学及下丘脑-垂体-肾上腺轴的影响[J]. 中国实验方剂学杂志, 2011,17(3):155-158. DOI：

WANG Jing-xia, ZHANG Jian-jun, MIAO Chun-ping, et al. Influences of Extract of Peony Radix Alba on Behavior and Hypothalamic-pituitary-adrenocortical Axis in Depressive Rats Model with Damaged Olfactory Bulb[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 155-158. DOI：

摘要

目的: 研究白芍提取物对嗅球损毁抑郁模型大鼠行为学及下丘脑-垂体-肾上腺(HPA)轴的影响。方法: 将嗅球损毁大鼠随机分为对照组、模型组、阳性药氟西汀2.5 mg ·kg-1 组以及白芍提取物70

17.5 mg ·kg-1 组

采用敞箱法、跳台法观察嗅球损毁大鼠的行为变化

同时用放免法分析白芍提取物对嗅球损毁大鼠下丘脑促肾上腺皮质激素释放素(CRH)、垂体促肾上腺皮质激素(ACTH)和血清皮质酮(CORT)含量的影响。结果: 大鼠嗅球损毁后敞箱行为出现明显变化

水平运动和垂直运动显著增加

白芍提取物中、高剂量组可显著降低大鼠水平运动和垂直运动的得分;跳台试验中

造模后大鼠训练期和测试期的错误次数显著增加

白芍提取物中、高剂量组能显著降低嗅球损毁大鼠训练期和测试期的触电次数;嗅球损毁大鼠下丘脑CRH

垂体ACTH

血清CORT含量明显增加

白芍提取物中、高剂量组能显著降低嗅球损毁大鼠CRH

ACTH

CORT的含量。结论: 白芍提取物能明显改善嗅球损毁大鼠的行为活动

并且对嗅球损毁大鼠亢进的HPA 轴功能的调整作用是白芍提取物治疗抑郁症的机制之一。

Abstract

Objective: To investigate the influences of extract from Peony Radix Alba on the behavioral and hypothalamic-pituitary-adrenocortical (HPA) axis changes in rats with damaged olfactory bulb (DOB). Method: The tests of open-field and step-down passive avoidance were used to observe the behaviors of rats. Radioimmunoassay (RIA) was used to analyze the level of corticotropin releasing hormone (CRH) in hypothalamus

adrenocorticotropic hormone (ACTH) in pituitary gland and cortisol (CORT) in serum of rats with DOB. Result: The rats had a characteristic hyperactivity in the test of "open-field" and learning deficits in step-down passive avoidance (P<0.05)

and their levels of CRH

ACTH and CORT increased significantly (P<0.05). The extract of Peony Radix Alba at the dose of 70

35 mg ·kg-1 corrected the behavioral changes (P<0.05) and decreased the levels of CRH

ACTH and CORT (P<0.05). Conclusion: The extract of Peony Radix Alba can correct behavioral changes in rats with DOB

and its regulating effect on HPA axis is one of the mechanisms for treating depression.

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