Objective: To investigate the interventions of taurine and vitamin in atherosclerosis (AS) induced by hyperhomoaysteine(HHcy) in rabbits. Method: The model groups with HHcy were respectively fed with taurine

folic acid

vitamin B6 and vitamin B12-a high L-methionine diet.Compared with the control group(NC)

the serum of the model groups were tested respectively in the 4th week and 8th week to determine the content of Hcy

MDA

TC

TG

NO

TXB2 and the activity of SOD and the changes in abdominal artery disease by vascular ultrasound and histologyical observation. Result: The contents of Hcy

MDA

ET and TXB2 in the serum of the rabbits having received methionine increased a lot(P<0.01

P<0.05) in the 4 week and 8 week than that of the control group

but the content of NO and the activity of SOD were much lower(P<0.01)

compared with the NC group in the same period.Hcy in the rabbits having received taurine were much higher

but Hcy in the rabbits having received vitamin displayed on change in the 8 week.And the contents of MDA

ET and TXB2 in both model groups were much lower (P<0.01) than the group with methionine

but the contents of NO and the activity of SOD were much higher(P<0.01).In the group with methionine Hcy could obviously induce abdominal arterial lesions with intimal thickening

smooth muscle cell hyperplasia

elastic fiber fracture

sort disorder and fatty plaque.Compared with the NC group

the rabbits received taurine and those received vitamin displayed no arterial lesions

no fatty plaque with neat structure. Conclusion: Taurine can resist the destrucion induced by Hcy.Vitamin can promote Hcy metabolism

inhibit vascular damage induced by Hcy and delay or prevent AS.