Objective: The efficacy of transdermal absorbent enhancement for four kinds of Chinese traditional medicine Angelica sinensis

Syringa oblata

Salvia miltiorrhiza

Cinnamomum cassia on the different structure substance was evaluated

which will provide the theoretical basis for the selection of Chinese medicine of cosmetics. Method: The guinea pig abdominal skin was used as the skin model; the polysaccharide (seaweed polysaccharide)

peptides (oat peptides) and flavonoids (Licorice flavonoids) were used as the objects to be promoted; azone was used as the positive reference. The experiment of Franz diffusion cell was used to evaluate the transdermal absorbent enhancement of four medicines to the different substance. Result: The efficacy of transdermal absorption enhancement was: A. sinensis>S. oblata>S. miltiorrhiza>azone>C. cassia. The quantity of the transdermal absorption enhancement was investigated

which showed that 0.8% A. sinensis ≥ 1% azone. Conclusion: There were no obvious structure-activity relationships between transdermal absorption enhancement and the targets. The mechanism is concluded to be the theory of stratum corneum structural changing.