补肾调周法对卵巢早衰模型大鼠血清INHB, VEGF的影响

张大伟; 李翠萍; 黄霞; 张丹丹; 范迎丽; 张越; 贺文婧

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补肾调周法对卵巢早衰模型大鼠血清INHB, VEGF的影响

更新时间：2024-01-04

- 补肾调周法对卵巢早衰模型大鼠血清INHB, VEGF的影响
- Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor
- 中国实验方剂学杂志 2011年17卷第12期页码：213-216
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省科技厅资助项目(092102310322)
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- 纸质出版日期：2011
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张大伟, 李翠萍, 黄霞, 等. 补肾调周法对卵巢早衰模型大鼠血清INHB, VEGF的影响[J]. 中国实验方剂学杂志, 2011,17(12):213-216.

ZHANG Da-wei, LI Cui-ping, HUANG Xia, et al. Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 213-216.
张大伟, 李翠萍, 黄霞, 等. 补肾调周法对卵巢早衰模型大鼠血清INHB, VEGF的影响[J]. 中国实验方剂学杂志, 2011,17(12):213-216. DOI：

ZHANG Da-wei, LI Cui-ping, HUANG Xia, et al. Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 213-216. DOI：

摘要

目的: 探讨补肾调周法对卵巢早衰模型大鼠血清抑制素B(INHB)、血管内皮生长因子(VEGF)水平的影响。方法: 90只大鼠随机分为9组

即空白对照组

模型对照组

补肾Ⅰ号方高、低剂量(68.67

34.30 g ·kg-1)组

补肾Ⅱ号方高、低剂量(61.40

30.70 g ·kg-1)组

补肾调周高、低剂量组

分别序贯给药Ⅰ号

Ⅱ号高、低剂量(每2天轮换一次)

阳性对照组

每组各10只。除空白对照组外其余各组均采用环磷酰胺(CTX)造模。给药20 d后

ELLSA法测定各组大鼠血清INHB

VEGF水平

光镜下观察卵巢的病理组织形态。结果: 补肾调周法能显著提高血清INHB

VEGF水平

从而提高卵巢的贮备能力

并能增加各级卵泡与黄体组织数量。结论: 补肾调周法可提高卵巢早衰模型大鼠的卵巢储备能力

这可能是对卵巢早衰早期干预的机制之一。

Abstract

Objective: To study effects of the self-made series of prescriptions of invigorating kidney and regulating periphery. On inhibin B(INHB) and vascular endothelial growth factor(VEGF) in rats with premature ovarian failure(POF). Method: Ninety rats were randomly divided into 9 groups(n=10):the blank control group

model control group

positive control group

the group of high dose Ⅰprescription of invigorating kidney(68.67 g ·kg-1)

the group of low dose Ⅰprescription of invigorating kidney(34.30 g ·kg-1)

the group of high dose Ⅱprescription of invigorating kidney(61.40 g ·kg-1)

the group of low dose Ⅱ prescription of invigorating kidney(30.70 g ·kg-1)

the group of high dose prescription of invigorating kidney and regulating menstruatinon

the group of low dose prescription of invigorating kidney and regulating menstruatinon.In addition to the blank control group

the other groups were induced as POF models by CTX.After 20 days’ treatments

the serum levels of INHB and VEGF were detected

and structure of ovary was observed under the lightmicroscope. Result: The method of invigorating kidney and regulating menstruation could obviously increase the serum levels of INHB and EGF

and increase all kinds of follicles and the quantity of the yellow body organization of the ovary. Conclusion: The method of invigorating kidney could improve the ability of ovarian reserve in POF rats.This might be one of the mechanisms of early intervention for premature ovarian failure.

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