春砂仁挥发油羟丙基--环糊精包合物的稳定性及增溶作用研究

张生潭; 汪铁山; 林敬明

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春砂仁挥发油羟丙基--环糊精包合物的稳定性及增溶作用研究

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- 春砂仁挥发油羟丙基--环糊精包合物的稳定性及增溶作用研究
- Study on Stability and Solubilization of Oil Hydroxypropyl--cyclodextrin Inclusion Complex
- 中国实验方剂学杂志 2011年17卷第4期页码：53-56
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- 基金信息：
  
  2008年广州市科技支撑计划 (2008Z1-E61)
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- 纸质出版日期：2011
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张生潭, 汪铁山, 林敬明. 春砂仁挥发油羟丙基--环糊精包合物的稳定性及增溶作用研究[J]. 中国实验方剂学杂志, 2011,17(4):53-56.

ZHANG Sheng-tan, WANG Tie-shan, LIN Jing-ming. Study on Stability and Solubilization of Oil Hydroxypropyl--cyclodextrin Inclusion Complex[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 53-56.
张生潭, 汪铁山, 林敬明. 春砂仁挥发油羟丙基--环糊精包合物的稳定性及增溶作用研究[J]. 中国实验方剂学杂志, 2011,17(4):53-56. DOI：

ZHANG Sheng-tan, WANG Tie-shan, LIN Jing-ming. Study on Stability and Solubilization of Oil Hydroxypropyl--cyclodextrin Inclusion Complex[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 53-56. DOI：

摘要

目的 :考察砂仁挥发油包合物的稳定性及羟丙基-β-环糊精对挥发油的增溶作用。方法: 以乙酸龙脑酯和樟脑的为考察指标

采用HPLC测定包合物及物理混合物中乙酸龙脑酯及樟脑的含量

在高温高湿及强光照的条件下进行试验

并采用相溶解度法测定羟丙基-β-环糊精对挥发油的增溶作用。结果 :在高温高湿及强光照条件下

包合物中乙酸龙脑酯及樟脑的含量均明显高于物理混合物中的两种成分的含量

增溶试验显示羟丙基-β-环糊精在50%浓度下可提高挥发油的溶解度约35倍。结论: 包合物抗高温、高湿、强光照较物理混合物强

且羟丙基-β-环糊精可明显增加砂仁挥发油的溶解度。

Abstract

Objective: To investigate the stability of volatile oil inclusion from Amomum and solubilization of volatile oil by hydroxypropyl-β-cyclodextrin. Method: The content of bornyl acetate and camphor in inclusion complex and physical mixture under the high temperature

humidity and strong light conditions was determined by HPLC with bornyl acetate and camphor as index and the solubilization of the volatile oil by hydroxypropyl-β-cyclodextrin was determined by phase solubility method. Result: Under the high temperature

humidity and strong light conditions

the content of bornyl acetate and camphor in inclusion was higher than that of in physical mixture

the results of solubility test showed that 50% concentration of hydroxypropyl-β-cyclodextrin could increase the solubility of essential oil of about 35 times. Conclusion: The inclusion complex had higher capability on anti high temperature

high humidity and strong light intensity than the physical mixture

and the hydroxypropyl-β-cyclodextrin could increase the solubility of essential oil significantly.

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