Objective: To optimize the extraction technology of Rhizome Cimicifugae. Method: The content of total saponins (measured by cimicifuga glycosides H-1) and total phenolic acids (the sum of ferulic acid

isoferulic acid and caffeic acid) was selected as the evaluation index for the first time. Orthogonal test was carried out to achieve the best extraction technology of Rhizome Cimicifugae by multiple guidelines grading methods. Result: The optimum extraction condition was that the medicinal materials were extracted 3 times with 6 times amout of 70% alcohol-0.1mol·L-1 HCl (95 ∶5) and for 1.5 hours per time. Conclusion: The optimum extraction condition was stable and feasible. It will provide a theoretical basis for regulating the extracting process of Rhizome Cimicifugae and lay the foundation to the further research and use of Rhizome Cimicifugae.