Objective: To dynamicaly observe the effects of pungent-hot herb decoction of Radix Aconiti Lateralis Preparata

Cortex Cinnamomi Aconite and Rhizoma Zingiberis on metabolism and second messenger. Method: Fourty Male SD rats were divided into two groups.The control group was given 4 mL of water; the experimental group was given 4 mL of pungent-hot decoction.About 2 mL blood samples were collected from orbit on 12th day

24 th day

36 th day

48 th day and 60 th day.Plasma GLU

TG

TC

TP levels were detected by automatic biochemical analyzer

Plasma cAMP

cGMP levels were determinated by radio-immunity. Result: Compared with the control group

the plasma GLU and TP levels changes with the trend of high→low→high

while cGMP level was significantly higher.The other parameters were not changed significantly. Conclusion: During the experimental process

there were significant fluctuation on metabolism and second messenger.It should pay more attention on the study of Yin deficiency model and choose administration time with the experimental requirements.