旋覆代赭汤对胃动力低下大鼠血液及组织中胃动素, 胃泌素及血管活性肠肽含量的影响

税典奎; 谢胜

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旋覆代赭汤对胃动力低下大鼠血液及组织中胃动素, 胃泌素及血管活性肠肽含量的影响

更新时间：2024-01-04

- 旋覆代赭汤对胃动力低下大鼠血液及组织中胃动素, 胃泌素及血管活性肠肽含量的影响
- Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility
- 中国实验方剂学杂志 2011年17卷第11期页码：161-164
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  湖北省卫生厅课题(200415)
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- 纸质出版日期：2011
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税典奎, 谢胜. 旋覆代赭汤对胃动力低下大鼠血液及组织中胃动素, 胃泌素及血管活性肠肽含量的影响[J]. 中国实验方剂学杂志, 2011,17(11):161-164.

SHUI Dian-kui, XIE Sheng. Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 161-164.
税典奎, 谢胜. 旋覆代赭汤对胃动力低下大鼠血液及组织中胃动素, 胃泌素及血管活性肠肽含量的影响[J]. 中国实验方剂学杂志, 2011,17(11):161-164. DOI：

SHUI Dian-kui, XIE Sheng. Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 161-164. DOI：

摘要

目的: 观察旋覆代赭汤对胃动力低下大鼠血液及胃窦组织中胃动素(MTL)、胃泌素(GAS)及血管活性肠肽(VIP)含量的影响。方法: 将70只大鼠随机分为正常组和模型组

正常组10只

模型组60只。模型组每只大鼠按10 g ·kg-1体重的甘草煎剂ig后

随机分为模型3 d组、模型7 d组、旋覆代赭汤低、中、高剂量组及吗丁啉组。吗丁啉组予2.7 g ·kg-1的吗丁啉混悬液ig

中药低、中、高各剂量组分别予3.69

7.38

14.76 g ·kg-1的旋覆代赭汤ig

共给药5 d。采用放免法观测各组大鼠血液及胃窦组织中MTL

GAS

VIP的含量。结果: 旋覆代赭汤各剂量组与模型组7 d组比较

可增加血液及组织中MTL含量(P<0.05或P<0.01)

中、高剂量组比吗丁啉组的作用更明显;可使大鼠血液中GAS含量上升(P<0.01)

中、高剂量组与吗丁啉组的作用相当;可降低血液及组织中VIP含量(P<0.05或P<0.01)

高剂量组对血液中及各剂量组对组织中VIP含量的影响与吗丁啉相当。结论: 旋覆代赭汤可通过调节脑肠肽在血液及组织中的含量达到促胃动力的作用。

Abstract

Objective: To observe the effect for Xuanfu Daizhe Decoction (XFDZD) on motilin (MTL)

gastrin (GAS) and vasoactive intestinal peptide (VIP) content in blood and tissue in rats with low gastric motility. Method: Seventy Wistar rats were divided into normal group (10 rats) and model group (60 rats) at random.Each rat of model group was irritated stomach with liquorice decoction (10 g ·kg-1).After stomach irritation

model group were divided into model group of 3 days

model group of 7 days

low

medium

high dosage groups of XFDZD

and the group of domperidone.The stomach with low gastric motility was irritated with domperidone

and the treatment groups were treated with XFDZD at different doses.Then the content of MTL

GAS

VIP in blood and gastric antrum was tested with radioimmunopercipitation. Result: Liquorice decoction could make rat model of low gastric motility.XFDZD could make MTL

GAS content increase in rat’s blood and organization

at the same time make VIP content reduce

campared with model groups

there were all significance difference (P<0.05 or P<0.01). Conclusion: XFDZD could treat disease of gastrointestinal dismotility by regulating brain-gut peptides content in rat's blood or gastric antrum.

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