抗柯萨奇B病毒性心肌炎胶囊复方水提物的 镇痛和抗应激作用

张博男; 韩淑英; 李洁; 马会霞; 郑彩慧; 姚荣妹; 董晓鹏; 王敏; 包巨太

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抗柯萨奇B病毒性心肌炎胶囊复方水提物的镇痛和抗应激作用

更新时间：2024-01-04

- 抗柯萨奇B病毒性心肌炎胶囊复方水提物的镇痛和抗应激作用
- Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities
- 中国实验方剂学杂志 2011年17卷第6期页码：133-135
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家"十一五"规划科技重大专项重大新药创制候选药物(2009ZX09103-442)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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张博男, 韩淑英, 李洁, 等. 抗柯萨奇B病毒性心肌炎胶囊复方水提物的镇痛和抗应激作用[J]. 中国实验方剂学杂志, 2011,17(6):133-135.

ZHANG Bo-nan, HAN Shu-ying, LI Jie, et al. Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 133-135.
张博男, 韩淑英, 李洁, 等. 抗柯萨奇B病毒性心肌炎胶囊复方水提物的镇痛和抗应激作用[J]. 中国实验方剂学杂志, 2011,17(6):133-135. DOI：

ZHANG Bo-nan, HAN Shu-ying, LI Jie, et al. Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 133-135. DOI：

摘要

目的: 观察抗柯萨奇B病毒性心肌炎胶囊(K-CoxB-JN)复方水提物镇痛作用和抗应激反应能力。方法: 健康昆明种小鼠随机分为5组

K-CoxB-JN复方水提物高剂量组、中剂量组、低剂量组

20 mL ·kg-1(给药量为9.6

4.8

2.4 g ·kg-1)

分别连续ig给药

并设阳性对照组及正常对照组。采用醋酸和热刺激致疼痛模型

考察其镇痛活性;采用游泳实验和耐缺氧实验

考察其抗应激作用。结果: K-CoxB-JN复方水提物对小鼠抗疲劳、耐缺氧等抗应激能力有一定的增强作用。相对于对照组

高剂量给药组可使小鼠游泳时间延长57 s

耐缺氧存活时间延长12 min;可以明显抑制醋酸引起的扭体次数

延长热板上小鼠舔后足出现的时间。相对于对照组

高剂量给药组可使小鼠扭体次数减少20次;中剂量给药组可使小鼠舔后足时间延长16 s。结论: K-CoxB-JN复方水提物具有明显的镇痛和抗应激作用。

Abstract

Objective: To study the anti-stress and analgesic activities of water extraction of K-CoxB-JN

a compound Chinese medicine for treatment of myocarditis. Method: Water extraction of K-CoxB-JN was consecutively given to healthy Kunming mice with high (9.6 g ·kg-1)

medium (4.8 g ·kg-1) and low dose (2.4 g ·kg-1) ig. At the same time

control group and positive group were set up. Analgesic activity was evaluated in mice model of pain induced by thermal stimulus and acetic acid. Meanwhile

anti-stress activity was evaluated by swimming and anti-hypoxia experiments. Result: Water extraction of K-CoxB-JN could enhance anti-stress capability of anti-fatigue and anti-hypoxia. The number of writhing induced by acetic acid was significantly reduced and the time of licking rear feet induced by hot plate stimulation was prolonged. Conclusion: Water extraction of K-CoxB-JN has good effects of anti-stress and analgesic capability.

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