YANG Qing, GAO Li, JIANG Xiao-fang, et al. Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 217-219.
YANG Qing, GAO Li, JIANG Xiao-fang, et al. Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 217-219.DOI:
且与鼻炎康组比较有统计学意义( P <0.05);辛芷鼻敏胶囊组大鼠鼻黏膜EOS计数明显低于模型组和鼻炎康组(P<0.01
P<0.05)。 结论 :辛芷鼻敏胶囊可以减少IL-5水平
减少嗜酸性粒细胞浸润
而起到一定的治疗作用。
Abstract
Objective: To investigate effect of Xinzhi Bimin capsule on the model of rats with allergic rhinitis(AR) and the effect on Interleukin-5(IL-5) and eosinophil(EOS). Method :Fourty rats were randomly divided into control group
sensitized group
the positive control (Beiyankang
3 g ·kg-1)and experimental groups(3.6 g ·kg-1).The rats were sensitized by ovalbumin. Result : IL-5 content in bone marrow of the experimental group was significantly lower than those of the model group and the positive control group(P<0.05); IL-5 content of blood serum in the experimental group was significantly lower than those of the model group and the positive control group(P<0.05); the numbers of EOS
compared with the control group and the model group
there were significant difference(P<0.05). Conclusion : Xinzhi Bimin capsule can reduce IL-5 content of bone marrow and in serum