Objective: Using multi-index comprehensive evaluation method to provide the production technology parameters of Wuji Wan. Method: The orthogonal test was employed with the index of the rate of extraction and the content of total alkaloid

paeoniflorin

evodiamine and rutaecarpine

optimizing the extraction process of Wuji Wan by multi-index comprehensive evaluation method. Result: Extraction times had much notable effect on experimental results and times

and the amount of ethanol had notable effect on the results. Ethanol concentration and extraction time had no notable effects. Considering the effects of five factors synthetically

the optimum process was A3B3C3D1

that was 80% ethanol

10 times the amount of ethanol

extraction 3 times and 1hour every time. Conclusion: The experimental method was steady and trusty

which will have some instruction meaning and reference value to the production of Wuji Wan.