Objective: To investigate the methods in copying the animal proliferative breast model. Method : We copied the animal proliferative breast model with different experimental programs

according to the theory of homogeneous design. And we evaluated varying degrees of success of these models with such indexes as the diameter of the mammilla

height of the mammilla and pathological dye of the galactophore. Result : Compared with the blank control group

the experimental group of animals’ nipple diameter and height were significantly increased in the breast tissue hyperplasia of mammary glands are typical

with the fifth

sixth group was the most obvious. Conclusion: The optimal conditions for establishing the model appear to be:estradiol benzoate 0.42-0.5mg ·kg-1

the duration for 25-35 days and progesterone 3-4.5 mg ·kg-1

intramuscular injection for 2-3 days.