The therapeutic effect of Chinese herb Triptergium wilfordii is significant and affirmative in immune rheumatic disease and renal diseases in clinical practice

but the toxicity limits its applications in many fields. Toxicity of T. wilfordii often bring damage to digestive system

reproductive system

hematological and immune system

so reducing toxicity but maintaining therapy effect has been focused on T. wilfordii studies in the past decade. Forty eight related articles on attenuating toxicity of Tripterygium from 1999 to 2011 have been searched and analyzed. In these literatures both traditional methods and Bi-directional solid fermentation technology can reduce the toxicity but maintaining therapy effect of Tripterygium. Traditional methods include formulation transform

processing

and combining with traditional Chinese medicine compounds. Advantage and disadvantage of each method on attenuating toxicity have been discussed. Bi-directional solid fermentation technology can provide new medicine and become new research approach. This technology is so promising and available

that it worth being further popularized. The mechanism of attenuating toxicity but maintaining therapy effect of Tripterygium will be disclosed with the aid of modern detection methods in order to pave the way on developing new medicine of Tripterygium preparation. By combining traditional Chinese medicine theory with modern pharmacology and Pharmacodynamics

more and more new methods for reducing toxicity but maintaining therapy effect of Tripterygium will be invented in years to come.