Objective: To investigate the effect of the Shenfu Yixin Granule on heart failure rats myocardial c-fos

c-myc expression. Method: Hear failure rats were produced by left anterior descending coronary artery occlusion in one hundred thirty heathly male SD rats. Twenty rats obtained the surgery without ligation as sham control. After 8 weeks

rats with left ventricle ejection fraction(LVEF)<50% were randomly Yixin assigned to 5 groups (n=10 in each group): model group

captopril group

losartan group

two groups of Shenfu Yixin Granule(5.48

21.90 g ·kg-1 ·d-1). All the medicine was taken orrally once a day for 4 weeks. The rats in model group and sham control (n=10) were administered equivalent water. After 4 weeks

The LVEF was valued with Color Doppler Ultrasound again. The left ventricular mass index (LVMI) was checked. The expression of c-fos

c-myc were detected respectively by immune-histochemisty technique. Result: Shenfu Yixin Granule(21.90 g ·kg-1 ·d-1) increased the LVEF

decreased LVMI and inhibited the expression of c-fos

c-myc. Conclusion: Shenfu Yixin Granules inhibit the expression of c-fos

c-myc in heart failure rats.