Objective: To observe the influence of Jinkui Shenqi Pill on sperm quality and renal function in rats with adenine-induced infertility. Method: Thirty adult male SD rats were randomly divided into Jinkui Shenqi Pill group

model group and control group. Sperm qualities of experimental rats were detected by automatic sperm quality analyzer

and contents of testosterone(T)

estradiol(E2)

luteinizing hormone(LH) and follicle-stimulating hormone(FSH) were measured by radioimmunoassay. Contents of BUN and Scr were ested by automatic biochemical analyzer. Renal tissue was observed by optical microscope. Testis was observed by transmission electron microscopy. Result : Jinkui Shenqi Pill could significantly improve symptoms of Shen-yang deficiency in adenine-induced infertility rats

and it could improve the sperm quality

including sperm density

sperm motility and sperm activity. It could increase content of T obviously

lower contents of E2

LH and FSH

lower contents of BUN and Scr. And it can better the damaged kidney tissue in model rats. Conclusion : Jinkui Shenqi pill can improve sperm quality significantly and improve function of kidney. And the mechanism of improving sperm quality may be related to the increase in content of T by stimulating the interstitial cells and lowering level of E2.