Objective: To study the effect of Xifeng Jingning Tang on immunologic function in mice with immunodepression. Method: The immunodepression mice model was induced by intraperitoneal injection of cyclophosphamide with 50 mg ·kg-1. Mice were administrated with Xifeng Jingning Tang at doses of 3

6

12 g ·kg-1 for 7 days.The phagocytic activity of monocytes

the delayed hypersensitivity reaction and the haemolysin antibody formation in mice were observed by means of carbon particle clearance

ear swelling and haemolysin antibodies respectively. Result: The doses of 6 and 12 g ·kg-1 ·d of Xifeng Jingning Tang could improve immune function in mice shown by carbon clearance index

phagocytic index and ear swelling. Xifeng Jingning Tang 12 g ·kg-1 could increase content of haemolysin antibody induced by cyclophosphamide. Conclusion: Xifeng Jingning Tang can improve non-specific immunity

and enhance specific cellular immunity and humoral immune function in immunodepression mice induced by cyclophosphamide.