Objective: To investigate the anti-inflammatory effect of Sedum lineare Thunb(SLT). Method: Three models were used to explore the anti-inflammatory effect of SLT. Two acute inflammatory models were made in mice

one was ear edema induced by d imethylbenzene

and the other was higher permeability of blood capillary induced by acetic acid. The chronic inflammatory model of granulation tissue was established by cotton pellets implantation in mice. Result: SLT suppressed the swelling of earflaps induced by dimethylbenzene

decreased the permeability of blood capillary induced by acetic acid obviously

and it significantly inhibited the proliferation of granulation tissue. SLT also decreased thoracic gland index and enhanced the spleen index in chronic inflammatory model. Conclusion: The SLT has obvious anti-inflammatory effect

which may result from modulating immune function.