Objective: To observe the effect of Jingyuankang capsule on the expression of apoptosis-related genes Caspase-3

Fas and FasL mRNA in bone marrow cells and make a study of the mechanism of the medicine. Method: Sixty mice were randomized into 5 groups:control group

model group

positive control group(Leucogen

32 mg ·kg-1)

Zhenqi Fuzheng group(3 g ·kg-1)

Jingyuankang group(4 g ·kg-1). The model was induced by ip cyclophosphamide(100 mg ·kg-1) for 3 days. Mean while the above treatments were given for 7 days. The expression of Caspase-3

Fas and FasL mRNA in bone marrow cells of model mice with myelosuppression was measured by real-time fluorescence quantitative PCR. Result: The Jingyuankang group had the lowest expression of Caspase-3

Fas and FasL mRNA

compared with that of the model group

the difference was significant;while compared with the control group

there was no significant differences. Conclusion: These results confirmed preliminarily that Jingyuankang capsule could decrease the expression of apoptosis-related genes Caspase-3

Fas and FasL

through affecting the apoptosis-related pathway to prevent the blood cells from apoptosis caused by chemotherapy.This might be an important mechanism of Jingyuankang capsule treating the chemotherapy-induced myelosuppression.